Method for preparing pyrrolidinyl urea derivative

A method for preparing of a compound represented by formula (I),

• comprising the following steps:
• step 1-1:
• reacting a compound represented by formula SM3-9 with a compound represented by formula SM3-10 to obtain a compound represented by formula SM3-11,
• step 1-2:
• reacting the compound represented by formula SM3-11 with a reagent Q to obtain a compound represented by formula SM3,
• step 2:1:
• reacting a compound represented by formula SM1 with a compound represented by formula 1-1 to obtain an intermediate compound, and which is reacted with a compound represented by formula SM2 to obtain a compound represented by formula 1-2,
• step 2-2:
• reacting the compound represented by formula 1-2 with a compound represented by formula 1-3 to obtain a compound represented by formula 1-4,
• step 3:
• reacting the compound represented by formula 1-4 with the compound represented by formula SM3 to obtain the compound represented by formula (I),
• wherein,
• reagent P is acetonitrile;
• reagent S-1 is potassium acetate;
• reagent S-2 is selected from tricyclohexylphosphine, 2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1-biphenyl, 2-(dicyclohexylphosphino)-3,6-dimethoxy-2-4-6-triisopropyl-1,1-biphenyl, triphenylphosphine and 2-dicyclohexylphosphino-2,4,6-triisopropylbiphenyl;
• solvent R is selected from tetrahydrofuran, dichloromethane and ethyl acetate;
• solvent X is selected from dichloromethane, N,N-dimethylformamide, tetrahydrofuran and ethyl acetate;
• solvent Z is selected from tetrahydrofuran/water, methyltetrahydrofuran, dichloromethane and methyltetrahydrofuran/water;
• reagent Q is selected from p-toluenesulfonic acid, hydrochloric acid and trifluoroacetic acid;
• catalyst U is selected from palladium acetate, (diphenylphosphino)ferrocene dichloropalladium(II), tetrakis(triphenylphosphine)palladium, allylpalladium(II) chloride dimer, di-μ-chlorobis[(1,2,3-η)-1-phenyl-2-propenyl]dipalladium(II) and palladium trifluoroacetate;
• base T is selected from sodium carbonate, cesium carbonate and potassium carbonate;
• base W is selected from pyridine, triethylamine, diisopropylethylamine and sodium bicarbonate;
• base Y is selected from sodium carbonate, diisopropylethylamine, triethylamine, pyridine, sodium bicarbonate, potassium carbonate and sodium hydroxide;
• and
• solvent V is selected from dioxane, methylcyclopentyl ether, toluene, methyltetrahydrofuran and tetrahydrofuran.