6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors

A compound of Formula I-1:

• or a pharmaceutically acceptable salt thereof, wherein:
• W is CRw or N;
• X is CRx or N;
• Y is CRy or N;
• Z is —O— or —NRz;
• Rw, Rx, and Ry are each independently hydrogen, halogen, —OR3, —N(R3)2, —SR3, optionally substituted C1-6 aliphatic, or —CN;
• Rz is hydrogen or optionally substituted C1-6 aliphatic;
• R1 is —N(R)2, —N(R)C(O)R′, —C(O)N(R)2, or —N(R)C(O)N(R)2;
• R2 is optionally substituted C1-6 aliphatic;
• R3 is hydrogen or optionally substituted C1-6 aliphatic;
• Ring A is optionally substituted 5- to 6-membered monocyclic heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, optionally substituted 8- to 10-membered bicyclic heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, optionally substituted 3- to 7-membered saturated or partially unsaturated monocyclic carbocyclyl, optionally substituted 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or optionally substituted 7- to 10-membered saturated or partially unsaturated bicyclic heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• L is a covalent bond or a bivalent C1-3 straight or branched hydrocarbon chain;
• Ra is hydrogen, halogen, optionally substituted C1-6 aliphatic, optionally substituted phenyl, optionally substituted 5- to 6-membered monocyclic heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, optionally substituted 3- to 7-membered saturated or partially unsaturated monocyclic carbocyclyl, optionally substituted 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or optionally substituted 7- to 10-membered saturated or partially unsaturated bicyclic heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each R is independently hydrogen, optionally substituted C1-6 aliphatic, optionally substituted 3- to 7-membered saturated or partially unsaturated carbocyclyl, or optionally substituted 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or two R when attached to the same nitrogen atom are taken together form an optionally substituted 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 0-2 additional heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• and
• each R′ is independently optionally substituted C1-6 aliphatic or optionally substituted 3- to 7-membered saturated or partially unsaturated carbocyclyl.