2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
AssigneeBoehringer Ingelheim International GmbH
InventorsStephan Georg Mueller, Kelly Allers, Klaus Klinder, Ursula Mueller-Vieira, Henning Priepke, Alexander Pautsch
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Abstract
The present invention relates to novel 2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamides of formula A and pharmaceutically acceptable salts thereof, wherein R1 to R3 are as defined herein. The invention also relates to processes for the preparation of these compound, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment or prevention of conditions in which inhibition of the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme may be beneficial.
Claims18
A compound of formula A
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 represents chloro or bromo;
- R2 represents hydrogen or fluoro;
- and
- R3 represents chloro or bromo.
Dependencies are inferred from the claim text.