Enantioselective cross dehydrogenative coupling reactions and compounds synthesized by the reactions
AssigneeNorthwestern University
InventorsKarl A. Scheidt, Ansoo Lee, Richard C. Betori
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Abstract
Disclosed are enantioselective cross dehydrogenative coupling reactions for synthesizing tetrahydropyran compounds. Novel tetrahydropyran compounds may be synthesized by the disclosed methods as well as tetrahydropyran precursor compounds for synthesizing various naturally occurring compounds. The enantioselective cross dehydrogenative coupling reactions utilize in situ Lewis Acid activation in combination with oxidative formation of an oxocarbenium ion to provide a highly efficient and selective coupling reaction for synthesizing tetrahydropyran compounds.
Claims5
A complex having a formula represented as L.M2+(OTf)2, wherein M is a divalent metal, Tf is triflyl, and L has a formula:
- wherein R8 and R9 together form a 3-membered, 4-membered, 5-membered, or 6-membered carbocyclic ring;
- and
- R10 and R11 are alkyl.
Dependencies are inferred from the claim text.