Inhibition of Olig2 activity

A compound having the structure of Formula (IIA):

• wherein:
• each R1 is independently halogen, —CN, —NO2, —OH, —OCF3, —OCH2F, —OCF2H, —SR8, —N(R8)S(═O)2R9, —S(═O)2N(R8)2, —S(═O)R9, —S(═O)2R9, —C(═O)R9, —CO2R8, —N(R8)2, —C(═O)N(R8)2, —N(R8)C(═O)R9, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C7heterocycloalkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C6-C10aryl, or substituted or unsubstituted C2-C7heteroaryl;
• or two R1 are taken together to form a substituted or unsubstituted heterocyclic ring or a substituted or unsubstituted carbocyclic ring;
• R2 and R3 are each independently H, —CN, C1-C4alkyl, C3-C6cycloalkyl, or C2-C7heterocycloalkyl;
• R4 is H, halogen, —CN, —NO2, —OH, —OCF3, —OCH2F, —OCF2H, —SR8, —N(R8)S(═O)2R9, —S(═O)2N(R8)2, —S(═O)R9, —S(═O)2R9, —C(═O)R9, —CO2R8, —N(R8)2, —C(═O)N(R8)2, —N(R8)C(═O)R9, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C7heterocycloalkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C6-C10aryl, or substituted or unsubstituted C2-C7heteroaryl;
• wherein when n is 0, R4 is not halogen;
• R5 is halogen, —CN, —OH, —CF3, or substituted or unsubstituted C1-C6alkyl;
• R6 is —(C(R14)(R15))mN(R11)(R12);
• R11 and R12 are each —CH3;
• R13 is H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C7heterocycloalkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted —C1-C4alkylC6-C10aryl, or substituted or unsubstituted —C1-C4alkylC2-C7heteroaryl;
• each R14 and R15 are each independently H, or substituted or unsubstituted C1-C6alkyl;
• or R14 and R15 are taken together to form a 4-, 5-, 6-membered cycloalkyl ring;
• each R8 is independently H, or substituted or unsubstituted C1-C6alkyl;
• R9 is substituted or unsubstituted C1-C6alkyl;
• R10 is H, or C1-C4alkyl;
• m is 2-6;
• n is 0-4;
• or
• a pharmaceutically acceptable salt, solvate, or prodrug thereof.