Isoquinoline-steroid conjugates and uses thereof
AssigneeAerie Pharmaceuticals, Inc.
InventorsMitchell A. deLong, Eric Carlson, Casey Kopczynski, Jill M. Sturdivant, Cynthia Lichorowic
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Abstract
Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.
Claims18
A method of treating an eye disease or disorder in a subject in need thereof, comprising administering to the subject an effective amount of a compound having the formula:
- or a pharmaceutically acceptable salt thereof.
A method of treating an eye disease or disorder in a subject in need thereof, comprising administering to the subject an effective amount of a compound having the formula:
- R8—R10—R11
- or a pharmaceutically acceptable salt thereof;
- wherein
- R8 is
- R10 is
- and
- R11 is
Dependencies are inferred from the claim text.