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US 11,691,945 B2Granted
USP9X inhibitors
AssigneeProDeg, LLC
InventorsRichard Martinelli, Julian F. Bond
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds that inhibit DUBs, particularly USP9X. The invention also includes methods of inhibiting DUBs, including USP9X, and methods of treating cancers.
Claims23
A compound represented by Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein R1 and R10 are each independently selected from H, 2H, and substituted or unsubstituted alkyl;
- R2, R3, R4, R6, and R7 are each independently selected from H, 2H, halogen, substituted or unsubstituted alkyl, and substituted or unsubstituted alkoxy;
- R5 and R9 are each independently selected from H, 2H, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, and halogen;
- R8 is substituted or unsubstituted 1- to 4-carbon alkylene;
- R11 is a hydrophobic alkyl selected from substituted or unsubstituted alkyl and substituted or unsubstituted cycloalkyl;
- Z1, Z2, and Z3 are each independently selected from CH and N;
- X1 is selected from —O—, —S—, —NH—, —CH2—;
- X2 is selected from -L-NRA—, -L-NRAC(O)—, -L-C(O)—, -L-OC(O)—, -L-C(O)O—, -L-CH(COORA)—, -L-C(O)NRA-L-, and -L-C(O)NRAC(O)—, wherein RA is selected from H, 2H, and substituted or unsubstituted alkyl;
- L is a linker group —(CH2)nCRBCRC(CH2)n—, wherein RB and RC are each independently selected from H, 2H, and substituted or unsubstituted alkyl;
- and wherein each n is independently 0, 1, or 2;
- and
- m is 1, 2, 3, or 4.
10 more elements
A compound represented by Formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein R1, R2, R3, R4, R6, R7, and R8 are independently hydrogen or a substituted or unsubstituted alkyl;
- L is a linker group which is a substituted or unsubstituted, saturated or unsaturated 1 to 10 carbon alkylene;
- Z1, Z2, and Z3 are independently selected from N and CH;
- X1, X2, and X3 are independently H or halogen;
- n and m are independently 1, 2, 3, 4, or 5.
3 more elements
A compound selected from the followings:
Dependencies are inferred from the claim text.