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AssigneeCargill, Incorporated
InventorsCatherine Asleson Dundon, Pirkko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
A yeast cell of species Issatchenkia orientalis that is genetically modified to produce lactate, said yeast cell further having a deletion or disruption of (i) a native gene encoding a glycerol-3-phosphate dehydrogenase and/or a native gene encoding a glycerol-3-phosphatase, and (ii) a pyruvate decarboxylase gene, wherein the yeast cell contains an exogenous lactate dehydrogenase gene.
Dependencies are inferred from the claim text.