Incorporating multiple targets in trajectory optimization for radiotherapy treatment planning
AssigneesSiemens Healthineers International AG, The Board of Trustees of the Leland Stanford Junior University
InventorsChristopher Barry Locke, Santtu Ollila, Karl Kenneth Bush
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Abstract
Methods of treatment trajectory optimization for radiotherapy treatment of multiple targets include determining beam's eye view (BEV) regions and a BEV region connectivity manifold for each target group of a plurality of target groups separately. The information contained in the BEV regions and the BEV region connectivity manifolds for all target groups is used to guide an optimizer to find optimal treatment trajectories. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
Claims20
A method of trajectory optimization for radiotherapy treatment of multiple targets, the method comprising:
- providing a patient model including a plurality of planning target volumes (PTVs);
- defining a delivery coordinate space (DCS) having a plurality of vertices, each respective vertex defining a respective beam's eye view (BEV) plane;
- for each respective PTV of the plurality of PTVs:
- for each respective BEV plane of a respective vertex, evaluating a respective BEV score of each respective pixel of the respective BEV plane for the respective PTV based at least in part on a dose of the respective PTV from a respective beamlet originating from the respective vertex and passing through the respective pixel of the respective BEV plane;
- determining a PTV-specific threshold BEV score for the respective PTV based at least in part on the BEV scores of the pixels of the BEV planes for the respective PTV;
- for each respective BEV plane of the respective vertex, determining one or more respective BEV regions of the respective PTV by comparing each respective BEV score of the respective pixel for the respective PTV to the PTV-specific threshold BEV score;
- and
- determining a respective BEV region connectivity manifold for the respective PTV representing connections between BEV regions of adjacent vertices;
- and
- selecting one or more optimal treatment trajectories for irradiating the plurality of PTVs based on the BEV region connectivity manifolds for the plurality of PTVs.
A computer product comprising a non-transitory computer readable medium storing a plurality of instructions that when executed control a computer system to perform trajectory optimization for radiotherapy treatment of multiple targets, the instructions comprising:
- providing a patient model including a plurality of planning target volumes (PTVs);
- defining a delivery coordinate space (DCS) having a plurality of vertices, each respective vertex defining a respective beam's eye view (BEV) plane;
- for each respective PTV of the plurality of PTVs:
- for each respective BEV plane of a respective vertex, evaluating a respective BEV score of each respective pixel of the respective BEV plane for the respective PTV based at least in part on a dose of the respective PTV from a respective beamlet originating from the respective vertex and passing through the respective pixel of the respective BEV plane;
- determining a PTV-specific threshold BEV score for the respective PTV based at least in part on the BEV scores of the pixels of the BEV planes for the respective PTV;
- for each respective BEV plane of the respective vertex, determining one or more respective BEV regions of the respective PTV by comparing each respective BEV score of the respective pixel for the respective PTV to the PTV-specific threshold BEV score;
- and
- determining a respective BEV region connectivity manifold for the respective PTV representing connections between BEV regions of adjacent vertices;
- and
- selecting one or more optimal treatment trajectories for irradiating the plurality of PTVs based on the BEV region connectivity manifolds for the plurality of PTVs.
Dependencies are inferred from the claim text.