Methods of treating bacterial infections
AssigneeTheraDep Technologies, Inc.
InventorLiam O'Neill
Life of this patent
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Abstract
Methods for treating a bacterial infections, including drug-resistant bacterial infections, of a patient are described. The methods may include applying a non-thermal plasma and a liquid simultaneously to infected tissue of the patient, the liquid comprising at least one antibiotic and/or antiseptic and a penetration enhancing agent; wherein the non-thermal plasma has a frequency between 200 kHz and 600 kHz.
Claims20
A method of treating a bacterial infection of a patient, the method comprising:
- applying a non-thermal plasma and a liquid simultaneously to infected tissue of the patient, the liquid comprising at least one antibiotic and a penetration enhancing agent chosen from dimethyl sulfoxide, azone, urea, an essential oil, a pyrrolidone, an oxazolidinone, a terpene, a perpenoid, or a mixture thereof;
- wherein the liquid penetrates the infected tissue of the patient, and
- wherein the non-thermal plasma has a frequency between 200 kHz and 600 kHz.
A method of treating a bacterial infection of a patient, the method comprising:
- generating a non-thermal plasma with a plasma device, the non-thermal plasma having a frequency between 200 kHz and 600 kHz;
- and
- introducing a liquid aerosol into the non-thermal plasma, wherein the liquid aerosol comprises:
- at least one antibiotic, at least one antiseptic, or a combination thereof;
- and
- at least one penetration enhancing agent, wherein the at least one penetration enhancing agent is chosen from dimethyl sulfoxide, azone, urea, an essential oil, a pyrrolidone, a fatty acid, an oxazolidinone, a terpene, a perpenoid, or a mixture thereof, and
- contacting infected tissue of the patient with the non-thermal plasma and the liquid aerosol simultaneously while maintaining an electrode tip of the plasma device at a distance ranging from 1.0 cm to 5.0 cm from the infected tissue, wherein the infected tissue includes drug-resistant bacteria and the liquid aerosol deposits on the infected tissue in liquid form and penetrates the infected tissue.
A method of treating a bacterial infection of a patient, the method comprising:
- generating a non-thermal plasma having a frequency between 200 kHz and 600 kHz using a plasma device coupled to a tube, a proximal end of the tube containing an electrode tip of the plasma device, wherein the length of the tube is adjustable in a range from 2 cm to 4 cm;
- introducing a liquid aerosol into the non-thermal plasma, wherein the liquid aerosol comprises at least one antibiotic and a penetration enhancing agent;
- and
- contacting infected tissue of the patient with the non-thermal plasma and the liquid aerosol simultaneously, a distal end of the tube of the plasma device being proximate the infected tissue when applying the non-thermal plasma to the infected tissue;
- wherein the infected tissue includes drug-resistant bacteria chosen from Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacteriaceae, Staphylococcus aureus, Clostridium difficile, or a combination thereof, the liquid aerosol deposits on the infected tissue as a liquid that penetrates the infected tissue, and wherein applying the non-thermal plasma and the liquid aerosol kills the drug-resistant bacteria.
Dependencies are inferred from the claim text.