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US 11,690,969 B2Granted
Delivery of gases to the nasal airway
AssigneeOptiNose AS
InventorsPer Gisle Djupesland, Roderick Peter Hafner
Life of this patent
Estimating the term…
Abstract
A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.
Claims22
A pharmaceutical delivery device for delivering a substance and a gas to a nasal airway of a subject, comprising:
- a nosepiece configured to fit to one nostril of the subject in use;
- a mouthpiece fluidly connected to the nosepiece and configured to fit to an oral cavity of the subject in use, through which the subject in use exhales creating a flow of exhalation breath;
- a substance supply unit fluidly connected to the nosepiece and configured to provide the substance into the flow of exhalation breath for delivery to the nasal airway of the subject;
- and
- a gas generation unit fluidly connected to the nosepiece and configured to provide the gas into the flow of exhalation breath for delivery to the nasal airway of the subject, wherein the gas generation unit includes an air-permeable container, containing a powder.
2 more elements
A pharmaceutical delivery device for delivering a substance to a nasal airway of a subject, comprising:
- a nosepiece configured to fit to one nostril of the subject in use;
- a mouthpiece fluidly connected to the nosepiece and configured to fit to an oral cavity of the subject in use, through which the subject in use exhales creating a flow of exhalation breath;
- a substance supply unit fluidly connected to the nosepiece and configured to provide the substance into the flow of exhalation breath for delivery to the nasal airway of the subject;
- and
- a gas generation unit fluidly connected to the nosepiece and configured to generate carbon dioxide gas and provide the carbon dioxide gas into the flow of exhalation breath for delivery to the nasal airway of the subject, the gas generation unit including an air-permeable container, which contains a powder configured to react with, to the flow of exhalation breath to generate the carbon dioxide gas.
2 more elements
A pharmaceutical delivery device for delivering a substance and a gas to a nasal airway of a subject, comprising:
- a nosepiece configured to fit to one nostril of the subject in use;
- a mouthpiece fluidly connected to the nosepiece and configured to fit to an oral cavity of the subject in use, through which the subject in use exhales creating a flow of exhalation breath;
- a substance supply unit fluidly connected to the nosepiece and configured to provide the substance into the flow of exhalation breath for delivery to the nasal airway of the subject;
- and
- a gas generation unit fluidly connected to the nosepiece and configured to provide the gas into the flow of exhalation breath for delivery to the nasal airway of the subject, wherein the gas generation unit includes an air-permeable container.
2 more elements
Dependencies are inferred from the claim text.