Devices, systems, and methods for dry powder therapies
AssigneeVirginia Commonwealth University
InventorsPhilip Worth Longest, Michael Hindle, Dale Farkas, Susan Boc
Life of this patent
Estimating the term…
Abstract
Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.
Claims34
A containment unit for a dry powder inhaler (DPI), comprising one or more containing walls which enclose and protect a dry powder from external conditions, wherein the dry powder is or contains a medicament for oral inhalation or nasal administration;
- at least one inlet that defines an inlet orifice in the one or more containing walls that has a fixed geometry which does not change from use of the containment unit;
- at least one outlet that defines an outlet orifice in the one or more containing walls that has a fixed geometry which does not change from use of the containment unit, wherein the inlet and outlet orifices are spaced apart;
- and an interior space within the one or more containing walls that permits the dry powder to form a powder beds wherein the fixed geometry of the inlet orifice is configured to form an inlet air jet along a straight geometric line, wherein the powder bed lies outside the straight geometric line when the containment unit is in an orientation of use, and wherein a direct linear path exists between the at least one inlet and the at least one outlet.
A dry powder inhaler (DPI), comprising at least one containment unit (CU) comprising one or more containing walls which enclose and protect a dry powder from external conditions, wherein the dry powder is or contains a medicament for oral inhalation or nasal administration;
- at least one inlet for making an inlet orifice in the one or more containing walls;
- at least one outlet for making an outlet orifice in the one or more containing walls;
- and an interior space within the one or more containing walls that permits the dry powder to form a powder bed, wherein the interior space is a cylindrical cavity or an elliptical shape, wherein during a state of use, the powder bed lies outside a straight geometric line coaxial with a center axis of the at least one inlet, wherein the straight geometric line is coaxial with a center axis of the at least one outlet, and wherein the one or more containing walls include curved surfaces to either side of the at least one inlet.
Dependencies are inferred from the claim text.