Methods for photodynamic therapy
AssigneeDUSA Pharmaceuticals, Inc.
InventorsScott Lundahl, Michael Guttadauro
Life of this patent
Estimating the term…
Abstract
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
Claims21
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy, the method comprising:
- topically applying ALA to a treatment area to be treated with photodynamic therapy;
- after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment to provide a transepidermal water loss rate from the treatment area of 1.11 g/m2 hr or less;
- and
- removing the low density polyethylene barrier after 3 hours and then applying light to the treatment area.
A method of treating actinic keratosis comprising:
- applying 5-aminolevulinic acid (ALA) to an actinic keratotic lesion on the stratum corneum of an upper extremity;
- after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment to provide a transepidermal water loss from the treatment area of 1.11 g/m2 hr or less;
- and
- removing the low density polyethylene barrier after 3 hours and then applying light to the treatment area.
A method of treating actinic keratosis comprising:
- applying 5-aminolevulinic acid (ALA) to an actinic keratotic lesion on the stratum corneum of an upper extremity to provide a maximum plasma concentration of ALA of less than about 110 ng/mL, following application of the ALA to the lesion;
- covering a treatment area including the lesion with a low density polyethylene barrier prior to light treatment to provide a transepidermal water loss rate from the treatment area of 1.11 g/m2 hr or less;
- and
- removing the low density polyethylene barrier after 3 hours and then applying light to the treatment area.
Dependencies are inferred from the claim text.