Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen

A method of inducing an immune response to an antigen, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising:

• (A) a polymeric carrier cargo complex, comprising:
• a) a polymeric carrier comprising disulfide-crosslinked cationic peptides, as a carrier;
• and
• b) at least one immunostimulatory RNA (isRNA) molecule as a cargo,
• wherein the cationic components and the isRNA molecule of the polymeric carrier cargo complex are provided in a nitrogen to phosphor atoms (N/P) ratio in the range of 0.1-0.9,
• and
• (B) at least one protein or peptide antigen that is selected from the group consisting of:
• a) an antigen from a pathogen associated with infectious disease;
• b) an antigen associated with allergy or allergic disease;
• c) an antigen associated with autoimmune disease;
• and
• d) an antigen associated with a cancer or tumour disease,
• wherein said pharmaceutical composition lacks an mRNA component,
• wherein the cationic peptides each comprise a sequence selected from the group consisting of CR7-20C (SEQ ID NOs:
• 1-14),
• wherein the at least one protein or peptide antigen is a separate component of the pharmaceutical composition from the polymeric carrier cargo complex.