Methods of otoprotection against platinum-based antineoplastic agents
AssigneeDecibel Therapeutics, Inc.
InventorsJohn Lee, John R. Soglia, Qi-Ying Hu, Fuxin Shi
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Abstract
Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.
Claims10
A method of mitigating platinum-induced hearing loss in a human subject in need thereof, the method comprising (i) administering to the subject by intratympanically or transtympanically injecting an effective amount of a hypertonic composition comprising 0.5M-1.0M of a thiosulfate salt, and (ii) intravenously administering cisplatin to the subject 1 to 3 hours following step (i).
A method of mitigating platinum-induced hearing loss in a human subject in need thereof, the method comprising (i) administering to the subject by transtympanically injecting directly through a tympanic membrane an effective amount of a hypertonic composition comprising 1.0M of sodium thiosulfate and 1% (w/v) hyaluronan, and (ii) intravenously administering cisplatin to the subject 1 to 3 hours following step (i).
A method of mitigating platinum-induced hearing loss in a human subject in need thereof, the method comprising (i) creating a ventilation hole in the subject's tympanic membrane to allow air to escape the middle ear space upon transtympanic administration of a composition;
- (ii) administering to the subject by transtympanically injecting directly through the tympanic membrane an effective amount of a hypertonic composition comprising 1.0M of sodium thiosulfate and 1% (w/v) hyaluronan;
- and (iii) intravenously administering cisplatin to the subject 1 to 3 hours following step (ii).
Dependencies are inferred from the claim text.