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US 11,690,844 B2Granted
Pyrazolyl pyrimidinone compounds and the uses thereof
AssigneePurdue Research Foundation
InventorsDaniel P. Flaherty, Richard M. van Rijn, Val J. Watts, Jason A. Scott
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
Claims11
A compound having a formula (III)
- wherein
- R1 is a C1-C6 alkyl;
- R2 is a C1-C6 alkyl;
- and
- R5 represents five substituents, each independently selected from the group consisting of hydrogen, deuterium, halo, azido, cyano, nitro, hydroxy, amino, thio, carboxy, ester, amide, and derivatives thereof, and acyl, sulfoxyl, sulfonyl, phosphate, phosphoryl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, arylalkenyl, and arylalkynyl, each of which is optionally substituted;
- or any two adjacent substituents are taken together with the attached carbons form an optionally substituted cyclic or heterocyclic moiety.
3 more elements
A compound having a formula (IV)
- wherein
- R1 is a C1-C6 alkyl;
- R2 is a C1-C6 alkyl;
- and
- R5 represents five substituents, each independently selected from the group consisting of hydrogen, deuterium, halo, azido, cyano, nitro, hydroxy, amino, thio, carboxy, ester, amide, and derivatives thereof, and acyl, sulfoxyl, sulfonyl, phosphate, phosphoryl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, arylalkenyl, and arylalkynyl, each of which is optionally substituted;
- or any two adjacent substituents are taken together with the attached carbons form an optionally substituted cyclic or heterocyclic moiety.
3 more elements
A compound having a formula (V)
- wherein
- R1 is a C1-C6 alkyl;
- R2 is a C1-C6 alkyl;
- and
- R5 represents five substituents, each independently selected from the group consisting of hydrogen, deuterium, halo, azido, cyano, nitro, hydroxy, amino, thio, carboxy, ester, amide, and derivatives thereof, and acyl, sulfoxyl, sulfonyl, phosphate, phosphoryl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, arylalkenyl, and arylalkynyl, each of which is optionally substituted, and wherein at least one of the five substituents is not hydrogen;
- or any two adjacent substituents are taken together with the attached carbons form an optionally substituted cyclic or heterocyclic moiety.
3 more elements
Dependencies are inferred from the claim text.