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US 11,690,843 B2Granted
Preparation and composition for treatment of malignant tumors
AssigneeTaiho Pharmaceutical Co., Ltd.
InventorsAkihiro Miura, Hiroshi Sootome
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AssigneeTaiho Pharmaceutical Co., Ltd.
InventorsAkihiro Miura, Hiroshi Sootome
Estimating the term…
It is intended to provide a novel method for treating a cancer using an FGFR inhibitor that exhibits a remarkably excellent antitumor effect and has fewer side effects. The present invention provides a combination preparation for the treatment of a malignant tumor comprising a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, and one or more additional compound(s) having an antitumor effect or pharmaceutically acceptable salt(s) thereof, and a pharmaceutical composition comprising both the active ingredients. The present invention also provides an antitumor effect enhancer, an antitumor agent, a kit for malignant tumor treatment, etc. comprising a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.
A method for treating a tumor comprising administering
A method for enhancing the antitumor effect of one or more compound(s) having an antitumor effect or pharmaceutically acceptable salt(s) thereof, selected from the group consisting of tegafur/gimeracil/oteracil potassium, 5-fluorouracil, gemcitabine, paclitaxel, cisplatin, everolimus, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, and gefitinib, comprising administering said compound with (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.