Pharmaceutical resinate compositions and methods of making and using thereof

A solid oral pharmaceutical composition comprising:

• a mixture comprising:
• an ion exchange resin;
• at least one active agent capable of forming a complex with the ion exchange resin, wherein the at least one active agent comprises a drug susceptible to abuse;
• a binder;
• and
• a matrix material comprising a polymer having a molecular weight of about 500,000 Da to about 10,000,000 Da,
• wherein the composition, when administered to a patient in need thereof, provides a controlled release of the at least one active agent to the patient with a therapeutic effect for at least about 8 hours,
• wherein the composition releases about 10% to about 45% active agent after 1 hour, about 12.5% to about 55% (by weight) active agent after 2 hours, about 25% to about 65% (by weight) active agent after 4 hours, about 45% to about 85% (by weight) active agent after 6 hours and about 55% to about 95% (by weight) active agent after 8 hours, when measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at about 50 rpm in about 900 ml simulated gastric fluid at about 37° C., and
• wherein recovery of the at least one active agent is less than about 20% based on a syringeability test whereby the composition is subject to dissolution in 10 ml of water with agitation at room temperature for about 2 min and the resultant solution is aspirated with a 21-gauge needle.