Delivery systems

An article of clothing comprising:

• (i) a yarn, wherein the yarn includes an air-covered yarn;
• (ii) a cross-linked polymer matrix comprising:
• a polymer;
• and
• a biologically therapeutic active compound dispersed in the polymer, wherein the cross-linked polymer matrix is imbibed on the yarn completely or partially along its length providing an imbibed yarn that releases the biologically therapeutic active compound from the cross-linked polymer matrix;
• and
• (iii) non-imbibed yarn, wherein the cross-linked polymer matrix is not imbibed along its length;
• wherein the imbibed yarn and the non-imbibed yarn are in a woven or knitted configuration as an article of clothing that is washable and reusable as the article of clothing;
• wherein the article of clothing is constructed and configured to conform to at least one part of a body of a mammal, wherein the article of clothing is constructed and configured to provide skin of a mammal contact with the imbibed yarn;
• wherein the biologically therapeutic active compound released by the imbibed yarn is delivered to the skin of the mammal;
• and
• wherein the article of clothing is a sock, an undergarment, an elbow sleeve, a knee sleeve, a wrist band, an arm band, a pair of tights, a pair of leggings, or a glove.

An article of clothing comprising:

• (i) a yarn;
• (ii) a cross-linked polymer matrix comprising:
• a polymer;
• and
• a biologically therapeutic active compound dispersed in the polymer, wherein the cross-linked polymer matrix is imbibed on the yarn completely or partially along its length providing an imbibed yarn that releases the biologically therapeutic active compound from the cross-linked polymer matrix;
• and
• (iii) non-imbibed yarn, wherein the cross-linked polymer matrix is not imbibed along its length;
• wherein the imbibed yarn and the non-imbibed yarn are in a woven or knitted configuration as an article of clothing that is washable and reusable as the article of clothing;
• wherein the biologically therapeutic active compound is one or more compounds selected from methyl salicylate, ethyl salicylate, arnica oil, peppermint oil, menthol, lidocaine, benzocaine, capsaicin, nonivamide, niacinamide, cannabidiol, caffeine, and hydrocortisone;
• wherein the article of clothing is constructed and configured to conform to at least one part of a body of a mammal, wherein the article of clothing is constructed and configured to provide skin of the mammal contact with the imbibed yarn;
• wherein the biologically therapeutic active compound released by the imbibed yarn is delivered to the skin of the mammal;
• and
• wherein the article of clothing is a sock, an undergarment, an elbow sleeve, a knee sleeve, a wrist band, an arm band, a pair of tights, a pair of leggings, or a glove.