Implantable device for sustained release of a macromolecular drug compound
AssigneeCelanese EVA Performance Polymers LLC
InventorChristian Schneider
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Abstract
An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The membrane polymer matrix contains a hydrophobic polymer in combination with a hydrophilic compound, and the weight ratio of the hydrophobic polymer to the hydrophilic compound within the membrane polymer matrix ranges from about 0.25 to about 200.
Claims32
An implantable device for delivery of a macromolecular drug compound, the device comprising:
- a core having an outer surface, wherein the core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a first ethylene vinyl acetate copolymer having a melting temperature of from about 40° C. to about 60° C. as determined in accordance with ASTM D3418-15;
- and
- a membrane layer positioned adjacent to the outer surface of the core, wherein the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed, wherein the membrane polymer matrix contains a second ethylene vinyl acetate copolymer having a melting temperature of from about 40° C. to about 60° C. as determined in accordance with ASTM D3418-15 in combination with a hydrophilic compound, wherein the weight ratio of the second ethylene vinyl acetate copolymer to the hydrophilic compound within the membrane polymer matrix ranges from at least about 2.3 to about 99.
Dependencies are inferred from the claim text.