Targeted delivery of therapeutic agents to human adipocytes
AssigneeAptamiR Therapeutics, Inc.
InventorMarc Thibonnier
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Abstract
Compositions and methods relating to modulating thermogenic regulation are disclosed. The compositions and methods can be used to treat diseases or conditions such as obesity or cardiometabolic disorders such as type 2 diabetes mellitus, NAFLD and NASH. Compositions include an adipocyte-targeting composition that includes a therapeutic agent capable of modulating thermogenic regulation, a targeting element facilitating cellular uptake and delivery of the therapeutic agent to a targeted adipocyte, and liposomal particles comprising sphingomyelin, DMPC, and cholesterol, wherein the liposomal particles enhance intra-cellular penetration of the therapeutic agent and protect the therapeutic agent from degradation.
Claims24
An adipocyte-targeting composition comprising:
- (a) a therapeutic agent capable of modulating lipid oxidation and/or thermogenic regulation;
- (b) a targeting element facilitating cellular uptake and delivery of the therapeutic agent to a targeted adipocyte;
- and
- (c) liposomal particles comprising sphingomyelin, DMPC, and cholesterol, wherein the liposomal particles enhance intra-cellular penetration of the therapeutic agent and protect the therapeutic agent from degradation.
An adipocyte-targeting therapeutic agent comprising an oligonucleotide linked to Hexarelin via a disulfide bond.
Dependencies are inferred from the claim text.