Devices for therapeutic nasal neuromodulation and associated methods and systems

A device for providing therapeutic neuromodulation in a nasal region of a human patient for treating a condition, the device comprising:

• a therapeutic assembly comprising a plurality of individual and flexible struts that cooperatively define a deformable frame, wherein the frame is transformable between a low-profile delivery state, to facilitate delivery of the therapeutic assembly to a target site in a nasal cavity of a patient and proximate or inferior to a sphenopalatine foramen, and an expanded state,
• wherein each of the plurality of struts comprises one or more electrodes, such that, when in the expanded state, at least some of the struts are configured to place corresponding electrodes into direct contact with target tissue at the target site, the target tissue being associated with nerves innervating nasal mucosa, wherein at least some of the electrodes are configured to deliver non-therapeutic stimulating energy to the target tissue for the detection of one or more properties of tissue at the target site and some of the electrodes are configured to deliver therapeutic energy to the target tissue, wherein the electrodes are individually activatable in response to receipt of activation signals from a controller coupled to the therapeutic assembly and configured to control output of energy therefrom, such that electrodes in direct contact with the target tissue are configured to deliver therapeutic neuromodulation energy at a specific target depth to the target tissue in response to activation signals received from the controller based, at least in part, on the detected one or more properties of tissue at the target site while remaining electrodes that are not in direct contact with the target tissue are not activated.