Cognitive platform configured as a biomarker or other type of marker

A computer-implemented method for enhancing one or more cognitive skills in an individual to provide an indication of a neurodegenerative condition of the individual, said method being implemented using a computing device comprising a processing unit, a graphical user interface, and an input device, said method comprising:

• using the processing unit, executing a first trial at a first time interval, the first trial comprising:
• rendering a first instance of a primary task at the graphical user interface, the first instance of the primary task requiring a first primary response from the individual to the first instance of the primary task using the input device,
• wherein the primary task comprises one or more computerized stimuli or interactions comprising one or more interactive elements rendered at the graphical user interface,
• wherein the primary task comprises a time-varying task having a response deadline;
• rendering a second instance of the primary task with a first interference at the graphical user interface, the second instance of the primary task requiring a second primary response from the individual, using the input device, wherein the first interference comprises one or more graphical elements presented at the graphical user interface at one or more time intervals during the primary task;
• wherein the first interference is configured to divert the individual's attention from the second instance of the primary task and is rendered as an interruptor or a distraction,
• wherein the individual is instructed not to respond to the first interference that is configured as a distraction and to respond to the first interference that is configured as an interruptor;
• using the processing unit, executing a second trial at a second time interval that is subsequent to the first time interval, the second trial comprising:
• rendering a third instance of the primary task at the graphical user interface, the third instance of the primary task requiring a third primary response from the individual to the third instance of the primary task using the input device;
• rendering a fourth instance of the primary task with a second interference at the graphical user interface, the fourth instance of the primary task requiring a fourth primary response from the individual using the input device, wherein the second interference comprises the one or more graphical elements presented at the graphical user interface at the one or more time intervals during the primary task,
• wherein the processing unit is configured to adjust a difficulty level of the second interference in real-time in response to receiving one or more inputs from the individual via the input device, wherein adjusting the difficulty level comprises modifying one or more of a number, speed and size of the one or more graphical elements presented at the graphical user interface in real-time;
• wherein the second interference is configured to divert the individual's attention from the fourth instance of the primary task and is rendered as the interruptor or the distraction,
• wherein the individual is instructed not to respond to the second interference that is configured as the distraction and to respond to the second interference that is configured as the interruptor;
• receiving, with the processing unit via the input device, data indicative of the first primary response, the second primary response, the third primary response, and the fourth primary response;
• using the processing unit, analyzing one or more differences in the individual's performance from performing the primary task without interference and with interference at least in part by determining differences between the data indicative of the first primary response, the second primary response, the third primary response, and the fourth primary response, to determine at least one first indicator of the cognitive ability of the individual;
• and
• using the processing unit, generating a scoring output indicative of a likelihood of onset of a neurodegenerative condition of the individual and/or a stage of progression of the neurodegenerative condition based at least in part on applying a first predictive model to the at least one first indicator,
• wherein the scoring output comprises a classification output of the first predictive model,
• wherein the first predictive model is configured to classify the individual as having an amyloid positive status or an amyloid negative status based on the data indicative of the first primary response, the second primary response, the third primary response, and the fourth primary response.