System and method for camera-based quantification of blood biomarkers

A system for determination of a concentration of one or more blood biomarkers of a human subject, the system comprising one or more processors and a data storage device, the one or more processors configured to execute:

• a TOI module to receive a captured image sequence of light re-emitted from the skin of the human subject and to determine, using a first machine learning model trained with a hemoglobin concentration (HC) changes training set, bit values from a set of bitplanes in the captured image sequence that represent the HC changes of the subject, the set of bitplanes being those that are determined to approximately maximize a signal-to-noise ratio (SNR), the HC changes training set comprising bit values from each bitplane of images captured from a set of subjects for which HC changes are known;
• a quantification module to determine, using a second machine learning model trained using a blood biomarkers training set, concentration of one or more blood biomarkers, the blood biomarkers training set comprising previously determined HC change signals from other subjects and one or more blood panels from those subjects as ground truth data;
• and
• an output module to output the determined concentration of one or more blood biomarkers.