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US 11,690,528 B2Granted
Breath analysis system and methods for asthma, tuberculosis and lung cancer diagnostics and disease management
AssigneeTricornTech Taiwan
InventorsLi-Peng Wang, Chi-Lin Young, Chien-Lin Huang, Tsung-Kuan A. Chou
Life of this patent
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Abstract
Methods and systems are disclosed for the detecting of whether a subject has a lung disorder such as asthma, tuberculosis or lung cancer. Monitoring the subject's health and prognosis is also disclosed.
Claims20
A method for detecting whether a subject has a respiratory disease or for monitoring a subject with a respiratory disease, the method comprising:
- receiving, at a portable apparatus having a gas chromatograph coupled to a detector array, ambient air to be inhaled by the subject, wherein the portable apparatus includes the gas chromatograph and the detector array replaceably mounted to a substrate of the portable apparatus;
- filtering, by a volatile organic compound (VOC) filter, the ambient air to remove at least a portion of background VOC content in the ambient air;
- further filtering, by a nitric oxide (NO) filter, the ambient air to remove at least a portion of background NO content from the ambient air;
- providing, at the portable apparatus, at least a portion of the ambient air to the subject to be inhaled;
- receiving, at the portable apparatus, breath exhaled from the subject;
- contacting the breath exhaled from the subject with the gas chromatograph mounted to the substrate of the portable apparatus;
- producing, by the detector array coupled to the gas chromatograph and mounted to the substrate of the portable apparatus, an indicator based on the exhaled breath from the subject, the indicator being produced based at least in part on one or more analytes in the breath exhaled from the subject, and the indicator being indicative of one or more biomarkers in the exhaled breath;
- and
- analyzing, by an analysis circuit disposed on the portable apparatus, the indicator to determine whether the subject has the respiratory disease, wherein the determination is made based on an NO concentration level in conjunction with VOC detection from the breath exhaled from the subject.
6 more elements
A portable apparatus for detecting whether a subject has a respiratory disease or for monitoring a subject with the respiratory disease, the apparatus comprising:
- a gas chromatograph and a detector array replaceably mounted to a substrate, the gas chromatograph and the detector array adapted to receive exhaled breath from the subject, the detector array producing an indicator based at least in part on the one or more analytes in the breath exhaled from the subject, and the indicator being indicative of one or more biomarkers in the exhaled breath;
- a preconcentrator coupled to the gas chromatograph and the detector array, wherein the preconcentrator increases a concentration of one or more analytes in the exhaled breath and directs the increased concentration of the one or more analytes to the gas chromatograph;
- and
- an analysis circuit disposed on the portable apparatus to analyze the indicator to determine whether the subject has the respiratory disease, wherein the determination is made based on an NO concentration level in conjunction with VOC detection from the breath exhaled from the subject.
1 more element
A method for detecting whether a subject has a respiratory disease or monitoring a subject with a respiratory disease said method comprising:
- receiving, at a portable apparatus having a gas chromatograph coupled to a detector array, breath exhaled from said subject, wherein the portable apparatus includes the gas chromatograph and the detector array replaceably mounted to a substrate of the portable apparatus;
- increasing, by a preconcentrator on the portable apparatus, a concentration of one or more analytes in the breath exhaled from said subject;
- contacting the increased concentration of the one or more analytes with the gas chromatograph mounted to the substrate of the portable apparatus;
- producing, by the detector array on the portable apparatus, an indicator based on the exhaled breath from said subject, the indicator being produced based at least in part on the one or more analytes in the breath exhaled from said subject, and the indicator being indicative of one or more biomarkers in the exhaled breath;
- and
- analyzing, by an analysis circuit disposed on said portable apparatus, said indicator to determine an NO concentration level in conjunction with one or more VOCs from the breath exhaled from said subject.
3 more elements
Dependencies are inferred from the claim text.