Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage

A method of treating a subject with microvascular obstructions (MO) or tissue necrosis in the heart, comprising:

• administering to the subject an effective amount of a composition comprising a chelating agent and one or more of an anti-inflammatory agent, a lipid-lowering agent, a carbon monoxide therapy, a heme-oxygenase regulating drug, and an agent capable of promoting heart blood flow in chronic phase of a myocardial infarction, wherein the subject has been diagnosed with the MO or tissue necrosis in the heart.

A method of treating a subject having had myocardial infarction (MI) and undergone reperfusion, or who has microvascular obstructions (MO) or tissue necrosis in the heart, comprising:

• administering to the subject an effective amount of a composition from 10 days to 15 days, from 15 days to 20 days, from 20 days to 25 days, from 25 days to 30 days, or from 56 days to 6 months since the onset of the MI, the MO or the tissue necrosis,
• wherein the composition comprises a chelating agent and one or more of an anti-inflammatory agent, a lipid-lowering agent, a carbon monoxide therapy, a heme-oxygenase regulating drug, and an agent capable of promoting heart blood flow.