Antimicrobial guanidinium and thiouronium functionalized polymers
AssigneesCoral Bay II, LLC, Agency for Science, Technology and Research
InventorsWilly Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
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Abstract
Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
Claims23
An antimicrobial cationic polymer, comprising a cationic subunit of formula (A-1):
- wherein
- atoms 1-6 are backbone atoms of the cationic polymer,
- m is 1 or 2,
- n is 0 or 1, wherein when m is 2, n is 0,
- each R′ is an independent monovalent radical selected from the group consisting of hydrogen and alkyl groups comprising 1 to 6 carbons,
- R″ is a monovalent radical selected from the group consisting of hydrogen and alkyl groups comprising 1 to 6 carbons, and
- each Q″ is an independent group comprising an isothiouronium group.
Dependencies are inferred from the claim text.