Systems and methods lattice spray substrates for mass spectrometry
AssigneeLawrence Livermore National Security, LLC
InventorsMaria C. Prieto Conaway, Joshua R. Deotte, Nikola Dudukovic, Eric B. Duoss, Bryan D. Moran
Life of this patent
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Abstract
The present disclosure relates to a lattice substrate adapted for use in direct ionization mass spectrometry. The substrate may have a plurality of tessellated unit cells forming an integral structure. Each tessellated unit cell may have a dimension of no more than about 1.5 mm and may include a plurality of pores arranged in an ordered pattern. The substrate may further include a form factor suitable for use with a direct ionization mass spectrometry system.
Claims17
A lattice substrate adapted for use in direct ionization mass spectrometry, the substrate comprising:
- a plurality of tessellated unit cells forming an integral structure, the tessellated unit cells each being formed by a plurality of intersecting filaments;
- each said tessellated unit cell having a dimension of no more than about 1500 μm, and including a first plurality of voids formed by the intersecting filaments, the first plurality of voids being arranged in a first ordered pattern;
- each said filament including a secondary lattice structure having a second plurality of voids formed by a plurality of struts that extend non-parallel to one another in three dimensions, the second plurality of voids also forming a second ordered three dimensional pattern;
- and
- a form factor suitable for use with a direct ionization mass spectrometry system.
A lattice substrate adapted for use in direct ionization mass spectrometry, the substrate comprising:
- a plurality of tessellated unit cells forming an integral, elongated flat structure with first and second ends, and one of the first and second ends forming a pointed end;
- each said tessellated unit cell having a dimension of no more than about 1.5 mm, and each said tessellated unit cell forming a plurality of internal voids acting as pores, with the pores arranged in an ordered pattern along a length of the substrate;
- the substrate including a form factor with a length and width each being greater than a thickness thereof;
- and
- the tessellated unit cells including Octet-truss shaped unit cells.
A method of constructing a lattice substrate adapted for use in direct ionization mass spectrometry, the method including:
- forming a substrate having a plurality of tessellated unit cells, each one of the tessellated unit cells having a plurality of intersecting filaments and the plurality of tessellated unit cells forming an integral structure;
- forming the tessellated unit cells such that each has a dimension of no more than about 1.5 mm, and such that each one of said tessellated unit cells includes a first plurality of voids arranged in an ordered pattern;
- further forming each said intersecting filament with a secondary lattice structure, the secondary lattice structure having a plurality of struts that extend and intersect in three non-parallel dimensions to form a second plurality of voids therein;
- and
- further forming the substrate with a form factor suitable for use with a direct ionization mass spectrometry system.
A lattice substrate adapted for use in direct ionization mass spectrometry, the substrate comprising:
- a plurality of tessellated unit cells having a plurality of intersecting filaments forming an integral structure;
- each said tessellated unit cell including a first plurality of voids, formed by the intersecting filaments, where the first plurality of voids extend in three dimensions in a first ordered pattern;
- each said filament comprises of a secondary lattice structure, with the secondary lattice structing including a plurality of intersecting struts extending non-parallel to one another in three dimensions, and forming a second plurality of voids extending in a three dimensional, second ordered pattern therewithin;
- and
- a form factor suitable for use with a direct ionization mass spectrometry system.
Dependencies are inferred from the claim text.