Systems and methods of validating motion correction of medical images for quantitative parametric maps

A motion correction validation system of validating motion correction of magnetic resonance (MR) images for a quantitative parametric map of a parameter, comprising a motion correction validation computing device, the motion correction validation computing device comprising at least one processor in communication with at least one memory device, and the at least one processor programmed to:

• receive a series of motion corrected images of a series of MR images, wherein the series of MR images are MR images of an anatomical region at different points of time;
• for each pixel of a plurality of pixels in one of the series of motion corrected images, the at least one processor programmed to:
• generate a time series at the pixel based on the series of motion corrected images;
• fit the time series to a model of the parameter;
• and
• estimate an indicator of goodness of fit of the time series to the model;
• generate a metric indicating effectiveness of the motion correction based on estimated indicators of goodness of fit of the plurality of pixels;
• and
• validate the motion correction based on the metric.

A computer-implemented method of validating motion correction of medical images for a quantitative parametric map of a parameter, comprising:

• receiving a series of motion corrected images of a series of medical images, wherein the series of medical images are medical images of an anatomical region at different points of time;
• for each pixel of a plurality of pixels in one of the series of motion corrected images, the method further comprising:
• generating a time series at the pixel based on the series of motion corrected images;
• fitting the time series to a model of the parameter;
• and
• estimating an indicator of goodness of fit of the time series to the model;
• generating a metric indicating effectiveness of the motion correction based on estimated indicators of goodness of fit of the plurality of pixels;
• and
• validating the motion correction based on the metric.