Methods of using OX40 ligand encoding polynucleotides
AssigneeModernaTX, Inc.
InventorsJoshua P. Frederick, Ailin Bai
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Abstract
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules comprising an mRNA encoding an OX40L polypeptide. Also provided is a method for activating T cells or increasing the number of NK cells in a subject in need thereof.
Claims37
A method for treating cancer in a subject having a solid tumor, the method comprising intratumorally administering to the subject a lipid nanoparticle (LNP) encapsulated messenger RNA (mRNA) encoding a human OX40L polypeptide, thereby treating cancer in the subject.
A method for treating cancer in a subject having a lymphoma, the method comprising administering to the subject an LNP encapsulated mRNA encoding a human OX40L polypeptide, thereby treating cancer in the subject.
Dependencies are inferred from the claim text.