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US 11,686,737 B2Granted
Dissolved protein arthritis markers
AssigneeThe University of British Columbia
InventorsAziz Ghahary, Wolodymyr Walter Peter Maksymowych, Ruhangiz Taghi Kilani
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Abstract
Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
Claims14
A method of detecting the eta isoform of the 14-3-3 protein in a patient, said method comprising:
- a. obtaining a test sample from a human patient at risk or suspected of having an inflammatory disorder of the joints of the body, wherein the test sample is selected from the group consisting of blood, serum, plasma, and synovial fluid;
- and
- b. detecting whether 14-3-3 eta protein is present in the test sample by contacting the test sample with an anti-14-3-3 eta protein antibody and detecting binding between 14-3-3 eta protein and the antibody.
A method of detecting the eta isoform of the 14-3-3 protein in a patient, said method comprising:
- a. obtaining a test sample from a human patient having pain, swelling, and stiffness in the joints of the body, wherein the test sample is selected from the group consisting of blood, serum, plasma, and synovial fluid;
- and
- b. detecting whether 14-3-3 eta protein is present in the test sample by contacting the test sample with an anti-14-3-3 eta protein antibody and detecting binding between 14-3-3 eta protein and the antibody.
The method according to claim , wherein said 14-3-3 eta isoform comprises the amino acid sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.