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US 11,686,736 B2Granted
Biomarkers to improve prediction of heart failure risk
OwnerChristie Mitchell Ballantyne, Ron Hoogeveen +2inventors
InventorsChristie Mitchell Ballantyne, Ron Hoogeveen, Vijay Nambi, Lloyd E. Chambless
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Abstract
The present disclosure relates to the field of laboratory diagnostics. Specifically, methods are disclosed for determining a patient's risk of suffering from heart failure (HF) based on the detection of NT-proBNP, troponin T, and/or a natriuretic peptide. Also disclosed are methods for improving both the accuracy and speed of HF risk models by incorporating biomarker data from patient samples.
Claims11
A method for diagnosing heart failure risk in a subject, the method consisting essentially of:
- (a) obtaining the subject's simplified model factors, wherein the simplified model factors are (i) age and race;
- or (ii) age, race and gender;
- (b) obtaining the amount of Troponin T (TnT) and the amount of NT-pro B-type natriuretic peptide (NT-proBNP) in a serum or plasma sample obtained from the subject;
- (c) calculating a simplified model score, using a computer comprising an evaluation unit, based on the amount of TnT and the amount of NT-proBNP in the biological sample obtained from the subject and the subject's simplified model factors, wherein the evaluation unit comprises a database with stored reference amounts of TnT and NT-proBNP and a computer program code;
- and
- (d) providing a diagnosis of heart failure risk based on the simplified model score calculated in step c).
3 more elements
Dependencies are inferred from the claim text.