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US 11,686,735 B2Granted
Systems and methods to identify and treat subjects at risk for obstetrical complications
AssigneesWayne State University, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsTinnakorn Chaiworapongsa, Roberto Romero, Sonia S. Hassan
Life of this patent
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Abstract
Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
Claims16
A method of treating an angiogenic and anti-angiogenic imbalance in a female human subject comprising:
- identifying the subject as having or at risk of the angiogenic and anti-angiogenic imbalance by a method comprising:
- obtaining a sample derived from the subject;
- assaying the sample for the concentration of PIGF and sVEGFR-1;
- analyzing the concentrations by assessing a ratio of PIGF/sVEGFR-1 in the sample;
- determining a Multiples of the Median (MoM) maternal plasma concentration ratio of PIGF/sVEGFR-1;
- comparing the determined MoM maternal plasma concentration ratio to a threshold;
- and
- identifying the subject as having or at risk of an angiogenic and anti-angiogenic imbalance based on the comparison of the MoM maternal plasma concentration ratio to the threshold, wherein a MoM concentration of <0.12 for PIGF/sVEGFR-1 is indicative of an angiogenic and anti-angiogenic imbalance;
- and
- administering an effective amount of a water-soluble statin to the subject, thereby treating the angiogenic and anti-angiogenic imbalance.
7 more elements
Dependencies are inferred from the claim text.