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US 11,686,705 B2Granted
Gel electrophoresis for DNA purification
AssigneeSeagate Technology LLC
InventorsGemma Mendonsa, Tim Rausch, Riyan Alex Mendonsa
Life of this patent
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Abstract
Systems and methods for identifying DNA strand size and purifying the DNA based on strand size using electrophoresis. The methods include moving, via voltage, a plurality of DNA strands through a separation gel from an inlet of a capillary or passage to either a first outlet or a second outlet dependent on the DNA strand length. In some implementations, the system is a capillary electrophoresis system. In other implementations, the system is a microfluidic lab-on-a-chip.
Claims13
A lab-on-a-chip electrophores is system comprising:
- a sample device comprising:
- a fluid path comprising a capillary structure having a main branch with an inlet at a first end, the capillary structure also having a first branch terminating at a first outlet and a second branch terminating at a second outlet, both the first outlet and the second outlet at a second end of the fluid path;
- a separation gel within the fluid path;
- and
- a voltage source configured to provide a voltage differential at the inlet, the first outlet and the second outlet, the voltage source configured to independently control the voltage differential at the first outlet and the second outlet in relation to the inlet;
- and
- a control device comprising:
- a control fluid path comprising a control capillary structure having an elongate, unbranched structure having a control inlet at a first end and a control outlet at a second end;
- a separation gel within the control fluid path;
- and
- a control voltage source configured to provide a voltage differential at the control inlet and the control outlet;
- wherein the sample device and the control device are on a lab-on-a-chip.
9 more elements
Dependencies are inferred from the claim text.