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US 11,685,952 B2Granted
Biomarker for predicting risk of recurrence in patients with paroxysmal atrial fibrillation
AssigneeKorea University Research and Business Foundation
InventorJong Il Choi
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Abstract
A method of providing information for predicting a risk of a recurrence after treatment of a patient with paroxysmal atrial fibrillation (AF) is provided. The method includes measuring a concentration of tissue inhibitor of metalloproteinase (TIMP)-1 from a sample isolated from a patient, and detecting a presence of a genetic variant at rs10033464 GG on chromosome 4q25 from nucleic acid separated from the sample.
Claims4
A method of predicting a risk of recurrence of paroxysmal atrial fibrillation (AF) in a patient after treatment of AF, the method comprising following steps:
- (1) obtaining a blood sample from the patient;
- (2) measuring a concentration of tissue inhibitor of metalloproteinase (TIMP)-1 of 107 ng/ml or greater in the sample;
- (3) detecting the presence of a G/T or T/T genotype of the rs10033464 polymorphism in nucleic acid from the sample;
- (4) predicting a high risk of recurrence of paroxysmal AF in said patient based on said measured concentration of TIMP-1 of 107 ng/ml or greater and said G/T or T/T genotype at rs10033464;
- and
- (5) treating said patient with an additional treatment for AF, wherein said additional treatment is a pharmacological treatment for AF.
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