Biomarkers for intracranial aneurysm
AssigneeThe Research Foundation for The State University of New York
InventorsHui Meng, Vincent Tutino
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Abstract
Provided are methods for determining a presence of an intracranial aneurysm in a subject suspected of having an intracranial aneurysm or at risk for developing an intracranial aneurysm, or a subject in need of aneurysm monitoring. The method involves analyzing a biological sample from the subject for expression of a combination of biomarkers that provide a signature of an aneurism.
Claims4
A method comprising analyzing a neutrophil sample from a subject for expression of biomarkers comprising neutrophil RNA expression, wherein determining expression of the biomarkers that is different from a control neutrophil RNA expression obtained from individuals who do not have an intracranial aneurysm indicates the presence of an intracranial aneurysm in the subject, and wherein analyzing the biological sample comprises:
- i) determining that expression of the following neutrophil RNA expression biomarkers is increased relative to the control:
- PVRL2, CYP1B1, CD177, PDE9A, ARMC12, OLAH, TGS1, CD163, LOC100506229, OCLN, SEMA6B, ADTRP, VWA8, MTRNR2L1, HOXB2, EPCAM, and IL18R1,
- and
- ii) determining that expression of the following neutrophil RNA expression biomarkers is decreased by a statistically significant difference relative to the control:
- IGSF23, PTGES, G0S2, FCRL5, C1orf226, UTS2, HBG2, CYP26B1, and C1QL1, to thereby determine the presence of the intracranial aneurysm, the method further comprising treating the intracranial aneurysm with a flow diverter, endovascular coiling, or surgical clipping.
Dependencies are inferred from the claim text.