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US 11,685,949 B2Granted
Mutant pore
AssigneeOxford Nanopore Technologies PLC
InventorsLakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
Life of this patent
Estimating the term…
Abstract
The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.
Claims16
A mutant CsgG monomer comprising a variant of the sequence shown in SEQ ID NO:
- 2 which
- (a) comprises:
- R97W;
- R93W;
- R93Y and R97Y;
- or
- F191T;
- and/or
- (b) consisting of deletion of V105, A106 and I107;
- and/or
- (c) comprises deletion of one or more of positions R192, F193, I194, D195, Y196, Q197, R198, L199, L200 and E201.
8 more elements
An apparatus comprising a mutant CsgG monomer comprising a variant of the sequence shown in SEQ ID NO:
- 2 which comprises
- (a) R97W;
- R93W;
- R93Y and R97Y;
- or
- F191T;
- and/or
- (b) deletion of V105, A106 and I107;
- and/or
- (c) deletion of one or more of positions R192, F193, I194, D195, Y196, Q197, R198, L199, L200 and E201.
7 more elements
Dependencies are inferred from the claim text.