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US 11,685,925 B2Granted
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
AssigneeSynlogic Operating Company, Inc.
InventorsDean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Yves Millet, Adam Fisher
Life of this patent
Estimating the term…
Abstract
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
Claims17
A bacterium comprising at least one non-native gene or gene cassette for producing indole-3 acetate,
- wherein a first gene cassette comprises genes trpEfbr, trpD, trpC, trpB, and trpA, and a second gene cassette comprises genes aroGfbr, trpDH, ipdC, and iad1, and
- wherein the first gene cassette is operably linked to a fumarate and nitrate reductase (FNR)-responsive promoter, and wherein the second gene cassette is operably linked to a FNR-responsive promoter.
Dependencies are inferred from the claim text.