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US 11,685,923 B2Granted
Methods of enhancing translation ability of RNA molecules, treatments, and kits
AssigneeCornell University
InventorsSamie R. Jaffrey, Kate D. Meyer
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Abstract
The present invention relates to methods and a kit for enhancing the translation ability of an RNA molecule. The methods involve the use of an RNA molecule comprising a methylated adenosine residue in a 5′ untranslated region (UTR). Also disclosed are methods for eIF4E-independent translation of an RNA molecule and treatment methods.
Claims16
An mRNA molecule comprising:
- a heterologous 5′ untranslated region (UTR), wherein the 5′ untranslated region comprises an adenosine methylation motif, wherein the adenosine methylation motif is a nucleotide sequence DRACH, wherein D is A, G, or U;
- R is G or A;
- and H is A, C, or U;
- a modified residue in the adenosine methylation motif of the 5′ untranslated region (UTR), wherein the modified residue is a methylated adenosine residue;
- and
- a 5′ cap, wherein said mRNA molecule is a substrate of eIF4E-independent translation.
3 more elements
Dependencies are inferred from the claim text.