US 11,685,921 B2Granted

Molecules and agents for treating hepatitis B virus

AssigneeArcturus Therapeutics, Inc.

InventorsPattraranee Limphong, Kiyoshi Tachikawa, Christine Esau, Padmanabh Chivukula

Life of this patent

Estimating the term…

Abstract

This invention encompasses compounds and compositions useful in methods for medical therapy, in general, for inhibiting Hepatitis B virus in a subject. The compounds have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, and the compounds are targeted to a sequence of an HBV genome.

Claims11

Dependent claims

A compound comprising a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, wherein the compound has a duplex region of from 14 to 29 contiguous monomers in length, wherein the first strand is a sense strand for RNA interference and the second strand is an antisense strand for RNA interference, wherein the compound comprises a sequence of bases targeted to inhibit expression of an HBV genome, wherein the sense strand and the antisense strand are each independently selected from the group consisting of:

REF
SEQ
S/
HBV (Sense (S)-Antisense (AS))
POS
ID NO
AS
(5′-3′)
1777
1182
S
UNA-G/*/mArGmGrCmUrGmUrArGrGmCr
AmUrAmArAmUrU/*/UNA-U/*/dT
1777
1183
AS
mArAmUrUmUrAmUrGmCrCmUmAmCr
AmGrCmCrUmC/UNA-U/*/dT
1777
1184
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1185
AS
mArA/*/mUrUmUrAmUrGmCrCmUmAm
CrAmGrCmCrUmC/UNA-U/*/dT
1777
1186
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1187
AS
mArArUmUmUrArUrGmCrCmUrArCrAm
GmCmCrUmC/UNA-U/*/dT
1777
1188
S
UNA-G/*/rArGrGmCmUrGmUrArGrGmCr
AmUrArArAmUmU/*/UNA-U/*/dT
1777
1189
AS
mArAmUrUmU/*/rAmU/*/rGmCrCmU/
*/mAmC/*/rAmGrCmCrUmC/UNA-U/*/dT
1777
1190
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1191
AS
mArAmUrUmUrAmUrGmCrCmUmAmCrAm
GrCmCrUmA/UNA-U/*/dT
1777
1192
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1193
AS
mArAmUrUdUrAmUrGmCrCmUmAmCr
AdGrCmCrUmC/UNA-U/*/dT
1777
1194
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1195
AS
rArAmUmUmUrAmUrGmCmCmUrAmCr
ArGmCmCmUmC/UNA-U/*/dT
1777
1196
S
UNA-G/*/rArGrGfCfUrGfUrArGrGf
CrAfUrArArAfUfU/*/UNA-U/*/dT
1777
1197
AS
rArAfUrUfUrAfUrGfCfCfUrAfCr
ArGfCfCfUfC/UNA-U/*/dT
1777
1198
S
UNA-G/*/fArGfGrCfUrGfUrArGrGf
CrAfUrAfArAfUrU/*/UNA-U/*/dT
1777
1199
AS
fArAfUrUfUrAfUrGfCrCfUfAfCr
AfGrCfCrUfC/UNA-U/*/dT
380
1200
S
UNA-U/*/mGrUmCrUmGrCmGrGrCrGm
UrUmUrUmArUmCrA/*/UNA-U/*/dT
380
1201
AS
mUrGmArUmArAmArAmCrGmCmCmGr
CmArGmArCmA/UNA-U/*/dT
380
1202
S
UNA-U/*/rGmUmCmUrGmCrGrGmCrGm
UmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1203
AS
mUrG/*/mArUmArAmArAmCrGmCmCm
GrCmArGmArCmA/UNA-U/*/dT
380
1204
S
UNA-U/*/rGmUmCmUrGmCrGrGmCrGm
UmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1205
AS
mUrGrAmUmArArArAmCrGmCrCrGr
CmAmGmArCmA/UNA-U/*/dT
380
1206
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1207
AS
mU/*/rGmArU/*/mArAmArAmCrGm
CmCmGrC/*/mArGmArC/*/mA/UNA-U/*/dT
380
1208
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1209
AS
mUrGmArUmArAmArAmCrGmCmCm
GrCmArGmArCmC/UNA-U/*/dT
380
1210
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1211
AS
mUrGmArUdArAmArAmCrGmCmCm
GrCdArGmArCmA/UNA-U/*/dT
380
1212
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1213
AS
mUrGrAmUrArArArAmCrGmCmCrGm
CrArGrAmCrA/UNA-U/*/dT
380
1214
S
UNA-U/*/rGfUfCfUrGfCrGrGfCr
GfUfUfUfUrAfUfCrA/*/UNA-U/*/dT
380
1215
AS
fUrGrAfUrArArArAfCrGfCfCrGf
CrArGrAfCrA/UNA-U/*/dT
380
1216
S
UNA-U/*/fGrUfCrUfGrCfGrGrCrGf
UrUfUrUfArUfCrA/*/UNA-U/*/dT
380
1217
AS
fUrGfArUfArAfArAfCrGfCfCfGr
CfArGfArCfA/UNA-U/*/dT
1575
1218
S
UNA-C/*/mCrGmUrGmUrGmCrArCr
UmUrCmGrCmUrUmCrA/*/UNA-U/*/dT
1575
1219
AS
mUrGmArAmGrCmGrAmArGmUmGm
CrAmCrAmCrGmG/UNA-U/*/dT
1575
1220
S
UNA-C/*/mCrGmUrGmUrGmCrAmCm
UrUrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1221
AS
mUrG/*/mArAmGrCmGrAmArGmUm
GmCrAmCrAmCrGmG/UNA-U/*/dT
1575
1222
S
UNA-C/*/mCrGmUrGmUrGmCrAmCm
UrUrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1223
AS
mUrGrAmAmGrCrGrAmArGmUrGrCr
AmCmAmCrGmG/UNA-U/*/dT
1575
1224
S
UNA-C/*/mCrGmUrGmUrGmCrAmCmUr
UrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1225
AS
mU/*/rGmArAmGrCmGrAmArGmU/*/
mGmC/*/rAmC/*/rAmCrGmG/UNA-U/*/dT
U/*/dT
1575
1226
S
UNA-C/*/mCrGmUrGmUrGmCrAmCmUr
UrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1227
AS
mUrGmArAmGrCmGrAmArGmUmGmCr
AmCrAmCrGmA/UNA-U/*/dT
1575
1228
S
UNA-C/*/mCrGmUrGmUrGmCrAmCmUr
UrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1229
AS
mUrGmArAdGrCmGrAmArGmUmGmCr
AdCrAmCrGmG/UNA-U/*/dT
1575
1230
S
UNA-C/*/mCrGmUrGmUrGmCrAmCm
UrUrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1231
AS
mUrGrArArGmCrGrArArGmUrGmCr
AmCrAmCrGrG/UNA-U/*/dT
1575
1232
S
UNA-C/*/fCrGfUrGfUrGfCrAfCfUf
UfCrGfCfUrUfCrA/*/UNA-U/*/dT
1575
1233
AS
fUrGrArArGfCrGrArArGfUrGfCr
AfCrAfCrGrG/UNA-U/*/dT
1575
1234
S
UNA-C/*/fCrGfUrGfUrGfCrArCr
UfUrCfGrCfUrUfCrA/*/UNA-U/*/dT
1575
1235
AS
fUrGfArAfGrCfGrAfArGfUfGfCr
AfCrAfCrGfG/UNA-U/*/dT
1575
1236
S
UNA-U/*/mGrUmGrCmArCmUrUrCr
GmCrUmUrCmArCmCrU/*/UNA-U/*/dT
1575
1237
AS
mArGmGrUmGrAmArGmCrGmAmAmGr
UmGrCmArCmA/UNA-U/*/dT
1578
1238
S
UNA-U/*/mGrUmGrCmArCmUrUrCrGm
CrUmUrCmArCmCrU/*/UNA-U/*/dT
1578
1239
AS
mArGmGrUmGrAmArGmCrGmAmAmGr
UmGrCmArCmA/UNA-U/*/dT
1578
1240
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1241
AS
mArG/*/mGrUmGrAmArGmCrGmAmAm
GrUmGrCmArCmA/UNA-U/*/dT
1578
1242
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1243
AS
mArGrGmUmGrArArGmCrGmArArGrUm
GmCmArCmA/UNA-U/*/dT
1578
1244
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGmCm
UmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1245
AS
mArGmGrU/*/mGrAmArGmCrGmAmAmGr
U/*/mGrC/*/mArC/*/mA/UNA-U/*/dT
1578
1246
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1247
AS
mArGmGrUmGrAmArGmCrGmAmAmGr
UmGrCmArCmC/UNA-U/*/dT
1578
1248
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1249
AS
mArGmGrUdGrAmArGmCrGmAmAmGrUd
GrCmArCmA/UNA-U/*/dT
1578
1250
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1251
AS
rArGrGmUrGrArArGmCrGrArArGmUr
GmCrAmCrA/UNA-U/*/dT
1578
1252
S
UNA-U/*/rGfUrGfCrAfCfUfUfCrGf
CfUfUfCrAfCfCfU/*/UNA-U/*/dT
1578
1253
AS
rArGrGfUrGrArArGfCrGrArArGf
UrGfCrAfCrA/UNA-U/*/dT
1578
1254
S
UNA-U/*/fGrUfGrCfArCfUrUrCrGf
CrUfUrCfArCfCrU/*/UNA-U/*/dT
1578
1255
AS
fArGfGrUfGrAfArGfCrGfAfAfGr
UfGrCfArCfA/UNA-U/*/dT
1576
1256
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1257
AS
mGrU/*/mGrAmArGmC/UNA-G/mArAm
GmUmGrCmArCmArCmG/UNA-U/*/dT
1576
1258
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1259
AS
mGrU/*/rGmAmArGrC/UNA-G/mAr
AmGrUrGrCmAmCmArCmG/UNA-U/*/dT
1576
1260
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1261
AS
mGrU/*/mGrAmArGmC/UNA-G/mArAmGmU/
*/mGrC/*/mArC/*/mArCmG/UNA-U/*/dT
1576
1262
S
UNA-C/*/rGmUrGmUrGmCrAmCmUm
UmCrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1263
AS
mGrUmGrAmArGmC/UNA-G/mArAmGm
UmGrCmArCmArCmA/UNA-U/*/dT
1576
1264
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1265
AS
mGrU/*/rGmAdArGrC/UNA-G/mArAm
GrUrGrCdAmCmArCmG/UNA-U/*/dT
1576
1266
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1267
AS
rGmUrGrArArGmC/UNA-G/rArArGmUr
GmCrAmCrAmCrG/UNA-U/*/dT
1576
1268
S
UNA-C/*/rGfUrGfUrGfCrAfCfUfUfCr
GfCfUfUfCrAfC/*/UNA-U/*/dT
1576
1269
AS
rGfUrGrArArGfC/UNA-G/rArArGfUr
GfCrAfCrAfCrG/UNA-U/*/dT
1576
1270
S
UNA-C/*/fGrUfGrUfGrCfArCrUrUfCr
GfCrUfUrCfArC/*/UNA-U/*/dT
1576
1271
AS
fGrUfGrAfArGfC/UNA-G/fArAfGfUf
GrCfArCfArCfG/UNA-U/*/dT
1578
1274
S
UNA-U/mGrUmGrCmArCmUrUrCrGmCrUm
UrCmArCmCrU/UNA-U/mU
1578
1275
AS
mArGmGrUmGrAmArGmCrGmAmAmGrUm
GrCmArCmA/UNA-U/mU
1578
1276
S
UNA-U/mGrUmGrCmArCmUrUrCrGmCrUm
UrCmArCmCrU/UNA-U/mU
1578
1277
AS
5Phos/mArGmGrUmGrAmArGmCrGmAmAm
GrUmGrCmArCmA/UNA-U/mU
1777
1278
S
UNA-G/mArGmGrCmUrGmUrArGrGmCrAmUr
AmArAmUrU/UNA-U/mU
1777
1279
AS
mArAmUrUmUrAmUrGmCrCmUmAmCrAmGr
CmCrUmC/UNA-U/mU
1777
1280
S
UNA-G/mArGmGrCmUrGmUrArGrGmCrAmUr
AmArAmUrU/UNA-U/mU
1777
1281
AS
5Phos/mArAmUrUmUrAmUrGmCrCmUmAmCr
AmGrCmCrUmC/UNA-U/mU
380
1282
S
UNA-U/mGrUmCrUmGrCmGrGrCrGmUrUmUr
UmArUmCrA/UNA-U/mU
380
1283
AS
mUrGmArUmArAmArAmCrGmCmCmGrCm
ArGmArCmA/UNA-U/mU
380
1284
S
UNA-U/mGrUmCrUmGrCmGrGrCrGmUrUm
UrUmArUmCrA/UNA-U/mU
380
1285
AS
5Phos/mUrGmArUmArAmArAmCrGmCmCm
GrCmArGmArCmA/UNA-U/mU,
SEQ ID NO:1107 (UNA-U*/mGrUmCrUmGrCmGrGrCrGmUrUmUrUmArUmCrA*/UNA-U*/mU) and SEQ ID NO:1108 (mUrGmArUmArAmArAmCrGmCmCmGrCmArGmArCmA/UNA-U*/mU);
and wherein “m” before a nucleotide denotes a chemically-modified 2′-OMe ribonucleotide, “r” before a nucleotide denotes a ribonucleotide, an asterisk * between characters refers to a phosphorothioate linkage, “d” before a nucleotide denotes a deoxyribonucleotide, “UNA” before a nucleotide denotes an unlocked nucleotide, and “f” before a nucleotide denotes a 2′-deoxy-2′-fluoro ribonucleotide.

518 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/724,122Filed 20 Dec 2019 · continuation
Priority: 17 Jul 2015
Published: US 2020/0131516 A130 Apr 2020
Granted: 27 Jun 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

C12N 15/1131
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against viruses
A61K 9/1271
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: non-conventional liposomes,…
A61K 47/6911
The form being a colloid or an emulsion: the form being a liposome
C12N 2310/14
Type of nucleic acid: interfering nucleic acids [NA]

Family

Application62/193,997Us provisional application · filed 17 Jul 2015
Application15/212,279Parent of this continuation-in-part · filed 17 Jul 2016
Application15/410,984Parent of this continuation · filed 20 Jan 2017
US 2020/0131516 A1Pre-grant publication · published 30 Apr 2020
Application15/410,984Parent of this continuation-in-part
US 2017/0016000 A1Published application
US 2017/0137821 A1Published application
US 11,685,921 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

REF
SEQ
S/
HBV (Sense (S)-Antisense (AS))
POS
ID NO
AS
(5′-3′)
1777
1182
S
UNA-G/*/mArGmGrCmUrGmUrArGrGmCr
AmUrAmArAmUrU/*/UNA-U/*/dT
1777
1183
AS
mArAmUrUmUrAmUrGmCrCmUmAmCr
AmGrCmCrUmC/UNA-U/*/dT
1777
1184
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1185
AS
mArA/*/mUrUmUrAmUrGmCrCmUmAm
CrAmGrCmCrUmC/UNA-U/*/dT
1777
1186
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1187
AS
mArArUmUmUrArUrGmCrCmUrArCrAm
GmCmCrUmC/UNA-U/*/dT
1777
1188
S
UNA-G/*/rArGrGmCmUrGmUrArGrGmCr
AmUrArArAmUmU/*/UNA-U/*/dT
1777
1189
AS
mArAmUrUmU/*/rAmU/*/rGmCrCmU/
*/mAmC/*/rAmGrCmCrUmC/UNA-U/*/dT
1777
1190
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1191
AS
mArAmUrUmUrAmUrGmCrCmUmAmCrAm
GrCmCrUmA/UNA-U/*/dT
1777
1192
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1193
AS
mArAmUrUdUrAmUrGmCrCmUmAmCr
AdGrCmCrUmC/UNA-U/*/dT
1777
1194
S
UNA-G/*/rArGrGmCmUrGmUrArGrGm
CrAmUrArArAmUmU/*/UNA-U/*/dT
1777
1195
AS
rArAmUmUmUrAmUrGmCmCmUrAmCr
ArGmCmCmUmC/UNA-U/*/dT
1777
1196
S
UNA-G/*/rArGrGfCfUrGfUrArGrGf
CrAfUrArArAfUfU/*/UNA-U/*/dT
1777
1197
AS
rArAfUrUfUrAfUrGfCfCfUrAfCr
ArGfCfCfUfC/UNA-U/*/dT
1777
1198
S
UNA-G/*/fArGfGrCfUrGfUrArGrGf
CrAfUrAfArAfUrU/*/UNA-U/*/dT
1777
1199
AS
fArAfUrUfUrAfUrGfCrCfUfAfCr
AfGrCfCrUfC/UNA-U/*/dT
380
1200
S
UNA-U/*/mGrUmCrUmGrCmGrGrCrGm
UrUmUrUmArUmCrA/*/UNA-U/*/dT
380
1201
AS
mUrGmArUmArAmArAmCrGmCmCmGr
CmArGmArCmA/UNA-U/*/dT
380
1202
S
UNA-U/*/rGmUmCmUrGmCrGrGmCrGm
UmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1203
AS
mUrG/*/mArUmArAmArAmCrGmCmCm
GrCmArGmArCmA/UNA-U/*/dT
380
1204
S
UNA-U/*/rGmUmCmUrGmCrGrGmCrGm
UmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1205
AS
mUrGrAmUmArArArAmCrGmCrCrGr
CmAmGmArCmA/UNA-U/*/dT
380
1206
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1207
AS
mU/*/rGmArU/*/mArAmArAmCrGm
CmCmGrC/*/mArGmArC/*/mA/UNA-U/*/dT
380
1208
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1209
AS
mUrGmArUmArAmArAmCrGmCmCm
GrCmArGmArCmC/UNA-U/*/dT
380
1210
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1211
AS
mUrGmArUdArAmArAmCrGmCmCm
GrCdArGmArCmA/UNA-U/*/dT
380
1212
S
UNA-U/*/rGmUmCmUrGmCrGrGmCr
GmUmUmUmUrAmUmCrA/*/UNA-U/*/dT
380
1213
AS
mUrGrAmUrArArArAmCrGmCmCrGm
CrArGrAmCrA/UNA-U/*/dT
380
1214
S
UNA-U/*/rGfUfCfUrGfCrGrGfCr
GfUfUfUfUrAfUfCrA/*/UNA-U/*/dT
380
1215
AS
fUrGrAfUrArArArAfCrGfCfCrGf
CrArGrAfCrA/UNA-U/*/dT
380
1216
S
UNA-U/*/fGrUfCrUfGrCfGrGrCrGf
UrUfUrUfArUfCrA/*/UNA-U/*/dT
380
1217
AS
fUrGfArUfArAfArAfCrGfCfCfGr
CfArGfArCfA/UNA-U/*/dT
1575
1218
S
UNA-C/*/mCrGmUrGmUrGmCrArCr
UmUrCmGrCmUrUmCrA/*/UNA-U/*/dT
1575
1219
AS
mUrGmArAmGrCmGrAmArGmUmGm
CrAmCrAmCrGmG/UNA-U/*/dT
1575
1220
S
UNA-C/*/mCrGmUrGmUrGmCrAmCm
UrUrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1221
AS
mUrG/*/mArAmGrCmGrAmArGmUm
GmCrAmCrAmCrGmG/UNA-U/*/dT
1575
1222
S
UNA-C/*/mCrGmUrGmUrGmCrAmCm
UrUrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1223
AS
mUrGrAmAmGrCrGrAmArGmUrGrCr
AmCmAmCrGmG/UNA-U/*/dT
1575
1224
S
UNA-C/*/mCrGmUrGmUrGmCrAmCmUr
UrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1225
AS
mU/*/rGmArAmGrCmGrAmArGmU/*/
mGmC/*/rAmC/*/rAmCrGmG/UNA-U/*/dT
U/*/dT
1575
1226
S
UNA-C/*/mCrGmUrGmUrGmCrAmCmUr
UrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1227
AS
mUrGmArAmGrCmGrAmArGmUmGmCr
AmCrAmCrGmA/UNA-U/*/dT
1575
1228
S
UNA-C/*/mCrGmUrGmUrGmCrAmCmUr
UrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1229
AS
mUrGmArAdGrCmGrAmArGmUmGmCr
AdCrAmCrGmG/UNA-U/*/dT
1575
1230
S
UNA-C/*/mCrGmUrGmUrGmCrAmCm
UrUrCmGmCmUmUmCrA/*/UNA-U/*/dT
1575
1231
AS
mUrGrArArGmCrGrArArGmUrGmCr
AmCrAmCrGrG/UNA-U/*/dT
1575
1232
S
UNA-C/*/fCrGfUrGfUrGfCrAfCfUf
UfCrGfCfUrUfCrA/*/UNA-U/*/dT
1575
1233
AS
fUrGrArArGfCrGrArArGfUrGfCr
AfCrAfCrGrG/UNA-U/*/dT
1575
1234
S
UNA-C/*/fCrGfUrGfUrGfCrArCr
UfUrCfGrCfUrUfCrA/*/UNA-U/*/dT
1575
1235
AS
fUrGfArAfGrCfGrAfArGfUfGfCr
AfCrAfCrGfG/UNA-U/*/dT
1575
1236
S
UNA-U/*/mGrUmGrCmArCmUrUrCr
GmCrUmUrCmArCmCrU/*/UNA-U/*/dT
1575
1237
AS
mArGmGrUmGrAmArGmCrGmAmAmGr
UmGrCmArCmA/UNA-U/*/dT
1578
1238
S
UNA-U/*/mGrUmGrCmArCmUrUrCrGm
CrUmUrCmArCmCrU/*/UNA-U/*/dT
1578
1239
AS
mArGmGrUmGrAmArGmCrGmAmAmGr
UmGrCmArCmA/UNA-U/*/dT
1578
1240
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1241
AS
mArG/*/mGrUmGrAmArGmCrGmAmAm
GrUmGrCmArCmA/UNA-U/*/dT
1578
1242
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1243
AS
mArGrGmUmGrArArGmCrGmArArGrUm
GmCmArCmA/UNA-U/*/dT
1578
1244
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGmCm
UmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1245
AS
mArGmGrU/*/mGrAmArGmCrGmAmAmGr
U/*/mGrC/*/mArC/*/mA/UNA-U/*/dT
1578
1246
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1247
AS
mArGmGrUmGrAmArGmCrGmAmAmGr
UmGrCmArCmC/UNA-U/*/dT
1578
1248
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1249
AS
mArGmGrUdGrAmArGmCrGmAmAmGrUd
GrCmArCmA/UNA-U/*/dT
1578
1250
S
UNA-U/*/rGmUrGmCrAmCmUmUmCrGm
CmUmUmCrAmCmCmU/*/UNA-U/*/dT
1578
1251
AS
rArGrGmUrGrArArGmCrGrArArGmUr
GmCrAmCrA/UNA-U/*/dT
1578
1252
S
UNA-U/*/rGfUrGfCrAfCfUfUfCrGf
CfUfUfCrAfCfCfU/*/UNA-U/*/dT
1578
1253
AS
rArGrGfUrGrArArGfCrGrArArGf
UrGfCrAfCrA/UNA-U/*/dT
1578
1254
S
UNA-U/*/fGrUfGrCfArCfUrUrCrGf
CrUfUrCfArCfCrU/*/UNA-U/*/dT
1578
1255
AS
fArGfGrUfGrAfArGfCrGfAfAfGr
UfGrCfArCfA/UNA-U/*/dT
1576
1256
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1257
AS
mGrU/*/mGrAmArGmC/UNA-G/mArAm
GmUmGrCmArCmArCmG/UNA-U/*/dT
1576
1258
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1259
AS
mGrU/*/rGmAmArGrC/UNA-G/mAr
AmGrUrGrCmAmCmArCmG/UNA-U/*/dT
1576
1260
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1261
AS
mGrU/*/mGrAmArGmC/UNA-G/mArAmGmU/
*/mGrC/*/mArC/*/mArCmG/UNA-U/*/dT
1576
1262
S
UNA-C/*/rGmUrGmUrGmCrAmCmUm
UmCrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1263
AS
mGrUmGrAmArGmC/UNA-G/mArAmGm
UmGrCmArCmArCmA/UNA-U/*/dT
1576
1264
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1265
AS
mGrU/*/rGmAdArGrC/UNA-G/mArAm
GrUrGrCdAmCmArCmG/UNA-U/*/dT
1576
1266
S
UNA-C/*/rGmUrGmUrGmCrAmCmUmUm
CrGmCmUmUrCrAmC/*/UNA-U/*/dT
1576
1267
AS
rGmUrGrArArGmC/UNA-G/rArArGmUr
GmCrAmCrAmCrG/UNA-U/*/dT
1576
1268
S
UNA-C/*/rGfUrGfUrGfCrAfCfUfUfCr
GfCfUfUfCrAfC/*/UNA-U/*/dT
1576
1269
AS
rGfUrGrArArGfC/UNA-G/rArArGfUr
GfCrAfCrAfCrG/UNA-U/*/dT
1576
1270
S
UNA-C/*/fGrUfGrUfGrCfArCrUrUfCr
GfCrUfUrCfArC/*/UNA-U/*/dT
1576
1271
AS
fGrUfGrAfArGfC/UNA-G/fArAfGfUf
GrCfArCfArCfG/UNA-U/*/dT
1578
1274
S
UNA-U/mGrUmGrCmArCmUrUrCrGmCrUm
UrCmArCmCrU/UNA-U/mU
1578
1275
AS
mArGmGrUmGrAmArGmCrGmAmAmGrUm
GrCmArCmA/UNA-U/mU
1578
1276
S
UNA-U/mGrUmGrCmArCmUrUrCrGmCrUm
UrCmArCmCrU/UNA-U/mU
1578
1277
AS
5Phos/mArGmGrUmGrAmArGmCrGmAmAm
GrUmGrCmArCmA/UNA-U/mU
1777
1278
S
UNA-G/mArGmGrCmUrGmUrArGrGmCrAmUr
AmArAmUrU/UNA-U/mU
1777
1279
AS
mArAmUrUmUrAmUrGmCrCmUmAmCrAmGr
CmCrUmC/UNA-U/mU
1777
1280
S
UNA-G/mArGmGrCmUrGmUrArGrGmCrAmUr
AmArAmUrU/UNA-U/mU
1777
1281
AS
5Phos/mArAmUrUmUrAmUrGmCrCmUmAmCr
AmGrCmCrUmC/UNA-U/mU
380
1282
S
UNA-U/mGrUmCrUmGrCmGrGrCrGmUrUmUr
UmArUmCrA/UNA-U/mU
380
1283
AS
mUrGmArUmArAmArAmCrGmCmCmGrCm
ArGmArCmA/UNA-U/mU
380
1284
S
UNA-U/mGrUmCrUmGrCmGrGrCrGmUrUm
UrUmArUmCrA/UNA-U/mU
380
1285
AS
5Phos/mUrGmArUmArAmArAmCrGmCmCm
GrCmArGmArCmA/UNA-U/mU,
SEQ ID NO:1107 (UNA-U*/mGrUmCrUmGrCmGrGrCrGmUrUmUrUmArUmCrA*/UNA-U*/mU) and SEQ ID NO:1108 (mUrGmArUmArAmArAmCrGmCmCmGrCmArGmArCmA/UNA-U*/mU);
and wherein “m” before a nucleotide denotes a chemically-modified 2′-OMe ribonucleotide, “r” before a nucleotide denotes a ribonucleotide, an asterisk * between characters refers to a phosphorothioate linkage, “d” before a nucleotide denotes a deoxyribonucleotide, “UNA” before a nucleotide denotes an unlocked nucleotide, and “f” before a nucleotide denotes a 2′-deoxy-2′-fluoro ribonucleotide.

518 more elements

Facts

Application

16/724,122Filed 20 Dec 2019 · continuation

Priority

17 Jul 2015

Published

US 2020/0131516 A130 Apr 2020

Granted

27 Jun 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C12N 15/1131
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against viruses
A61K 9/1271
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: non-conventional liposomes,…
A61K 47/6911
The form being a colloid or an emulsion: the form being a liposome
C12N 2310/14
Type of nucleic acid: interfering nucleic acids [NA]

Family

Application62/193,997Us provisional application · filed 17 Jul 2015

Application15/212,279Parent of this continuation-in-part · filed 17 Jul 2016

Application15/410,984Parent of this continuation · filed 20 Jan 2017

US 2020/0131516 A1Pre-grant publication · published 30 Apr 2020

Application15/410,984Parent of this continuation-in-part

US 2017/0016000 A1Published application

US 2017/0137821 A1Published application

US 11,685,921 B2This patent

From the US filing history. Foreign family members aren’t listed.