Compositions and methods for organoid generation and disease modeling
AssigneeThe Salk Institute for Biological Studies
InventorsRonald Evans, Michael Downes, Annette Atkins, Eiji Yoshihara, Ruth Yu
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Abstract
The invention features pancreatic islet and pancreatic organoids, and cell cultures and methods that are useful for the rapid and reliable generation of pancreatic islet and pancreatic islet organoids. The invention also features methods of treating pancreatic diseases and methods of identifying agents that are useful for treatment of pancreatic diseases, such as type 2 diabetes and pancreatic cancer, using the pancreatic islet and pancreatic organoids of the invention.
Claims19
A method of generating a functionally mature pancreatic islet organoid, the method comprising culturing an induced pluripotent stem cell (iPSC)-derived pancreatic islet organoid comprising an iPSC-derived beta-like cell in a medium comprising a Wnt4 or a Wnt5a polypeptide, or a fragment thereof, thereby generating the functionally mature pancreatic islet organoid.
Dependencies are inferred from the claim text.