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US 11,685,792 B2Granted
Antibodies against human CD39 and use thereof for inhibiting T regulatory cells activity
AssigneeInserm (Institut National De La Sante Et De La Recherche Medicale)
InventorsYves Levy, Jean-Francois Eliaou, Armand Bensussan, Nathalie Bonnefoy-Berard
Life of this patent
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Abstract
The invention relates to antibodies against human CD39 and use thereof for inhibiting T regulatory cells (Treg) activity. More particularly CD39 antibodies may be used for the treatment or prevention of cancers and infectious diseases.
Claims9
An anti-CD39 antibody or antigen binding fragment thereof comprising:
- a heavy chain wherein the variable domain comprises the sequence of SEQ ID NO:2 for CDR-H1, SEQ ID NO:3 for CDR-H2 and SEQ ID NO:4 for CDR-H3;
- and
- a light chain wherein the variable domain comprises the sequence of SEQ ID NO:6 for CDR-L1, SEQ ID NO:7 for CDR-L2 and SEQ ID NO:8 for CDR-L3.
Dependencies are inferred from the claim text.