Antibody binding specifically to N-terminal region of lysyl-tRNA synthetase exposed on cell membrane

An antibody or fragment thereof specifically binding to an epitope consisting of a sequence of SEQ ID NO:

• 101, SEQ ID NO:
• 106, or SEQ ID NO:
• 111 in the lysyl-tRNA synthetase (KRS) N-terminus, wherein the antibody or fragment thereof specifically binds to an extracellularly exposed lysyl-tRNA synthetase (KRS) N-terminal region, wherein the antibody or fragment thereof comprises a heavy chain variable region and a light chain variable region which are selected from the group consisting of:
• a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 1, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 3, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 5, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 7, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 9, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 11;
• a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 13, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 15, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 17, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 19, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 21, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 23;
• a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 25, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 27, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 29, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 31, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 33, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 35;
• and
• a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 37, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 39, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 41, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO:
• 43, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO:
• 45, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO:
• 47.