Antibodies binding to STEAP-1
AssigneeHoffmann-La Roche Inc.
InventorsThomas Hofer, Maximiliane Koenig, Ekkehard Moessner, Jens Niewoehner, Tina Weinzierl, Laurent Lariviere
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Abstract
The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
Claims1
An antibody that binds to STEAP-1, wherein the antibody comprises a heavy chain variable region (VH) comprising a heavy chain complementarity determining region (HCDR) 1 of SEQ ID NO:
- 1, a HCDR 2 of SEQ ID NO:
- 2, and a HCDR 3 of SEQ ID NO:
- 4, and a light chain variable region (VL) comprising a light chain complementarity determining region (LCDR) 1 of SEQ ID NO:
- 7, a LCDR 2 of SEQ ID NO:
- 8 and a LCDR 3 of SEQ ID NO:
- 9.
Dependencies are inferred from the claim text.