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US 11,685,784 B2Granted
Anti-immune-checkpoint nanobody and nucleic acid encoding sequence thereof, and uses of the same
AssigneeChina Medical University Hospital
InventorsDer-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
Life of this patent
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Abstract
The present disclosure provides an anti-immune-checkpoint nanobody that specifically binds to a programmed cell death ligand 1. The present disclosure also provides the nucleic acid sequence of the anti-immune-checkpoint nanobody, use of the anti-immune-checkpoint nanobody for treating cancer and immune-related disorders, and a method for detecting expression levels of PD-L1.
Claims19
An anti-immune-checkpoint nanobody that specifically binds to a programmed cell death ligand 1 (PD-L1), consisted of the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 3;
- wherein the anti-immune-checkpoint nanobody is produced and purified from Escherichia coli (E. coli) strain HB2151.
Dependencies are inferred from the claim text.