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US 11,685,782 B2Granted
Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy
AssigneesChildren's Medical Center Corporation, President and Fellows of Harvard College
InventorsYang Shi, Wanqiang Sheng, Arlene H. Sharpe, Martin W. LaFleur
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Abstract
Provided herein are methods of treating cancer using LSD1 inhibitors in combination with immunotherapy.
Claims21
A method of treating cancer in a patient, the method comprising:
- administering to a patient in need thereof a therapeutically effective amount of a lysine-specific demethylase 1A (LSD1) inhibitor to thereby treat cancer in the patient, wherein the LSD1 inhibitor comprises an inhibitory nucleic acid comprising SEQ ID NO:
- 2.
A method of treating cancer in a patient, the method comprising:
- administering to a patient in need of cancer treatment therapeutically effective amounts of a lysine-specific demethylase 1A (LSD1) inhibitor and at least one immunotherapy, to thereby treat cancer in the patient, wherein the LSD1 inhibitor comprises an inhibitory nucleic acid comprising SEQ ID NO:
- 2.
A method of treating cancer in a patient, the method comprising:
- administering to a patient in need thereof a therapeutically effective amount of a PD-L1 inhibitor to thereby treat cancer in the patient, wherein the PD-L1 inhibitor comprises an inhibitory nucleic acid comprising SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.