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US 11,685,780 B2Granted
Single domain antigen binding domains that bind human Trop2
AssigneeTakeda Pharmaceutical Company Limited
InventorsChad May, Robert B. Dubridge, Maia Vinogradova, Anand Panchal
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Abstract
The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen is B7H3.
Claims20
A single domain antigen binding domain (sdABD) that binds human Trop2, wherein the sdABD comprises:
- (i) a complementarity-determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:
- 78, a complementarity-determining region 2 (CDR2) comprising the amino acid sequence of SEQ ID NO:
- 79, and a complementarity-determining region 3 (CDR3) comprising the amino acid sequence of SEQ ID NO:
- 80;
- (ii) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 82, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 83, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 84;
- (iii) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 86, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 87, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 88;
- (iv) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 90, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 91, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 92;
- (v) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 94, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 95, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 96;
- or
- (vi) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 98, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 99, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 100.
22 more elements
Dependencies are inferred from the claim text.