Method of reducing blood glucose levels and inhibiting secreted aP2
AssigneePresident and Fellows of Harvard College
InventorsGokhan S. Hotamisligil, Haiming Cao
Life of this patent
Estimating the term…
Abstract
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.
Claims6
A method of reducing blood glucose levels in a human comprising administering to the human an effective amount of an Adipocyte Protein 2 (aP2)-specific antibody that specifically binds to aP2 in blood or serum.
Dependencies are inferred from the claim text.