Stabilized receptor polypeptides and uses thereof
AssigneeAmgen Inc.
InventorsJeonghoon Sun, Lei-Ting Tony Tam, Mark Leo Michaels, Thomas Charles Boone, Rohini Deshpande, Yue-Sheng Li, Huiquan Han
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Abstract
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
Claims6
An isolated protein comprising a stabilized activin IIB receptor polypeptide, wherein said stabilized activin IIB receptor polypeptide comprises:
- a polypeptide having the amino acid sequence identity of SEQ ID NO:
- 12, wherein the polypeptide has a W or a Y at position 28 and a T at position 44, wherein the polypeptide is capable of binding myostatin, activin A, or GDF-11.
Dependencies are inferred from the claim text.