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US 11,685,764 B2Granted
Separation matrix
AssigneeCytiva BioProcess R&D AB
InventorsGustav José Rodrigo, Tomas Bjorkman, Mats Ander, Jesper Ulf Hansson
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Abstract
The invention relates to a separation matrix comprising at least 11 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein: a) the ligands comprise multimers of alkali-stabilized Protein A domains, and b) the porous support comprises cross-linked polymer particles having a volume-weighted median diameter (d50, v) of 56-70 micrometers and a dry solids weight of 55-80 mg/ml.
Claims40
A separation matrix comprising at least 15 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein:
- a) said ligands comprise multimers of alkali-stabilized Protein A domains,
- b) said porous support comprises cross-linked polymer particles having a volume-weighted median diameter (d50, v) of from 56 micrometers to 70 micrometers and a dry solids weight of from 55 mg/ml to 80 mg/ml.
Dependencies are inferred from the claim text.